Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.

Abstract excerpt

Ca(2+) regulates voltage-gated Na(+) (NaV) channels, and perturbed Ca(2+) regulation of NaV function is associated with epilepsy syndromes, autism and cardiac arrhythmias. Understanding the disease mechanisms, however, has been hindered by a lack of structural information and competing models for how Ca(2+) affects NaV channel function. Here we report the crystal structures of two ternary complexes of a human NaV...

Topics

• Amino Acid Sequence
• Calcium
• Calmodulin
• Crystallography, X-Ray
• Cytosol
• Fibroblast Growth Factors
• Humans
• Kinetics
• Models, Molecular
• Molecular Sequence Data
• Mutagenesis, Site-Directed
• Mutation
• NAV1.2 Voltage-Gated Sodium Channel