Crystal structure of human myosin 1c--the motor in GLUT4 exocytosis: implications for Ca2+ regulation and 14-3-3 binding.

doi:10.1016/j.jmb.2014.03.004

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Article

Crystal structure of human myosin 1c--the motor in GLUT4 exocytosis: implications for Ca2+ regulation and 14-3-3 binding.

Journal of molecular biology - 15 May 2014

Münnich Stefan, Taft Manuel H, Manstein Dietmar J

Abstract excerpt

Myosin 1c (Myo1c) plays a key role in supporting motile events that underlie cell migration, vesicle trafficking, insulin-stimulated glucose uptake and hearing. Here, we present the crystal structure of the human Myo1c motor in complex with its light chain calmodulin. Our structure reveals tight interactions of the motor domain with calmodulin bound to the first IQ motif in the neck region. Several of the...

Topics

14-3-3 Proteins
Calcium
Calmodulin
Crystallography, X-Ray
Exocytosis
Glucose Transporter Type 4
Hearing Loss, Sensorineural
Humans
Models, Molecular
Mutation
Myosin Type I
Protein Binding
Protein Conformation
Protein Transport

Source

Open in PubMed

Identifiers

PMID: 24636949
DOI: 10.1016/j.jmb.2014.03.004

Provenance

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