Selective determinants of inositol 1,4,5-trisphosphate and adenophostin A interactions with type 1 inositol 1,4,5-trisphosphate receptors.

doi:10.1111/j.1476-5381.2010.00947.x

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Article

Selective determinants of inositol 1,4,5-trisphosphate and adenophostin A interactions with type 1 inositol 1,4,5-trisphosphate receptors.

British journal of pharmacology - 1 Nov 2010

Rossi Ana M, Sureshan Kana M, Riley Andrew M, Potter V L, Taylor Colin W

Abstract excerpt

BACKGROUND AND PURPOSE: Adenophostin A (AdA) is a potent agonist of inositol 1,4,5-trisphosphate receptors (IP(3) R). AdA shares with IP(3) the essential features of all IP(3) R agonists, namely structures equivalent to the 4,5-bisphosphate and 6-hydroxyl of IP(3) , but the basis of its increased...

Topics

Adenosine
Animals
Calcium
Calcium Channel Agonists
Inositol 1,4,5-Trisphosphate
Inositol 1,4,5-Trisphosphate Receptors
Male
Mutation
Protein Binding
Rats
Rats, Wistar

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