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Article

Disruption of Ca2+/calmodulin:KSR1 interaction lowers ERK activation.

Protein science : a publication of the Protein Society - 1 May 2024

Thines Louise, Jang Hyunbum, Li Zhigang, Sayedyahossein Samar, Maloney Ryan, Nussinov Ruth, Sacks David B

Abstract excerpt

KSR1, a key scaffold protein for the MAPK pathway, facilitates ERK activation upon growth factor stimulation. We recently demonstrated that KSR1 binds the Ca2+-binding protein calmodulin (CaM), thereby providing an intersection between KSR1-mediated and Ca2+ signaling. In this study, we set out to generate a KSR1 point mutant with reduced Ca2+/CaM binding in order to unravel the functional implications of their...

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Source

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Identifiers

PMID: 38591710
DOI: 10.1002/pro.4982
PMCID: PMC11002989

Genes

KSR1
CA3
EGF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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