Article
Calmodulin regulation and identification of calmodulin binding region of type-3 ryanodine receptor calcium release channel.
Biochemistry - 15 Nov 2005
Yamaguchi Naohiro, Xu Le, Pasek Daniel A, Evans Kelly E, Chen S R Wayne, Meissner Gerhard
Abstract excerpt
Ryanodine receptors (RyRs) are a family of intracellular Ca(2+) channels that are regulated by calmodulin (CaM). At low Ca(2+) concentrations (<1 microM), CaM activates RyR1 and RyR3 and inhibits RyR2. At elevated Ca(2+) concentrations (>1 microM), CaM inhibits all three RyR isoforms. Here we report that the regulation of recombinant RyR3 by CaM is sensitive to redox regulation. RyR3 in the presence of reduced...
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