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Article

Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate.

Scientific reports - 6 Jan 2017

Moniz Larissa S, Surinova Silvia, Ghazaly Essam, Velasco Lorena Gonzalez, Haider Syed, Rodríguez-Prados Juan Carlos, Berenjeno Inma M, Chelala Claude, Vanhaesebroeck Bart

Abstract excerpt

To identify novel effectors and processes regulated by PI3K pathway activation, we performed an unbiased phosphoproteomic screen comparing two common events of PI3K deregulation in cancer: oncogenic Pik3ca mutation (Pik3caH1047R) and deletion of Pten. Using mouse embryonic fibroblast (MEF) models that generate inducible, low-level pathway activation as observed in cancer, we quantified 7566 unique phosphopeptides...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28059163
DOI: 10.1038/srep39985
PMCID: PMC5216349

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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