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The ecology of cancer from an evolutionary game theory perspective

20 Jun 2014

Abstract excerpt

The accumulation of somatic mutations, to which the cellular genome is permanently exposed, often leads to cancer. Analysis of any tumour shows that, besides the malignant cells, one finds other 'supporting' cells such as fibroblasts, immune cells of various types and even blood vessels. Together, these cells generate the microenvironment that enables the malignant cell population to grow and ultimately lead to...

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PMID: 25097748
DOI: 10.1098/rsfs.2014.0019

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