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Article

Game-theoretical description of the go-or-grow dichotomy in tumor development for various settings and parameter constellations.

Scientific reports - 5 Oct 2023

Dwivedi Shalu, Glock Christina, Germerodt Sebastian, Stark Heiko, Schuster Stefan

Abstract excerpt

A medically important feature of several types of tumors is their ability to "decide" between staying at a primary site in the body or leaving it and forming metastases. The present theoretical study aims to provide a better understanding of the ultimate reasons for this so-called "go-or-grow" dichotomy. To that end, we use game theory, which has proven to be useful in analyzing the competition between tumors and...

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PMID: 37798314
DOI: 10.1038/s41598-023-43199-3
PMCID: PMC10555990

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