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Article

An evolutionary model of carcinogenesis.

Cancer research - 1 Oct 2003

Gatenby Robert A, Vincent Thomas L

Abstract excerpt

A quantitative model of carcinogenesis based on methods from population biology and game theory demonstrates normal cells in vivo occupy a ridge-shaped maximum in a well-defined tissue fitness landscape, a novel configuration that allows cooperative coexistence of multiple cellular populations. This state, although necessary for development of functioning multicellular organisms, is subject to invasion by fitter,...

Topics

Animals
Biological Evolution
Carcinoma
Cell Division
Colorectal Neoplasms
Game Theory
Humans
Models, Biological
Mutation
Neoplasm Invasiveness
Neoplasms

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PMID: 14559806

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