Improving Mathematical Models of Cancer through Game-Theoretic Modelling: A Study in Non-Small Cell Lung Cancer

Abstract excerpt

We examined a dataset of 590 Non-Small Cell Lung Cancer patients treated with either chemotherapy or immunotherapy using a game-theoretic model that includes both the evolution of therapy resistance and a cost of resistance. We tested whether the game-theoretic model provides a better fit than classical mathematical models of population growth (exponential, logistic, classic Bertalanffy, general Bertalanffy, Gompe...

Topics

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• Cancer Genomics and Diagnostics
• Carcinoma, Non-Small-Cell Lung
• Computer Simulation
• Drug Resistance, Neoplasm
• Lung Cancer Treatments and Mutations
• Lung Neoplasms
• Models, Theoretical
• Mutation

Identifiers and source

Literature Corpus work

9c074dab-0965-5626-a9b9-919e6d760bb5

DOI

10.1101/2021.10.29.466444