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Article

Rer1p regulates the ER retention of immature rhodopsin and modulates its intracellular trafficking.

Scientific reports - 6 Aug 2014

Yamasaki Akinori, Hara Taichi, Maejima Ikuko, Sato Miyuki, Sato Katsuya, Sato Ken

Abstract excerpt

Rhodopsin is a pigment in photoreceptor cells. Some rhodopsin mutations cause the protein to accumulate in the endoplasmic reticulum (ER), leading to photoreceptor degeneration. Although several mutations have been reported, how mutant rhodopsin is retained in the ER remains unclear. In this study, we identified Rer1p as a modulator of ER retention and rhodopsin trafficking. Loss of Rer1p increased the transport...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25096327
DOI: 10.1038/srep05973
PMCID: PMC4122963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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