Article
Subcellular localization of mutant P23H rhodopsin in an RFP fusion knock-in mouse model of retinitis pigmentosa.
Disease models & mechanisms - 1 May 2022
Robichaux Michael A, Nguyen Vy, Chan Fung, Kailasam Lavanya, He Feng, Wilson John H, Wensel Theodore G
Abstract excerpt
The P23H mutation in rhodopsin (Rho), the rod visual pigment, is the most common allele associated with autosomal-dominant retinitis pigmentosa (adRP). The fate of misfolded mutant Rho in rod photoreceptors has yet to be elucidated. We generated a new mouse model, in which the P23H-Rho mutant allele is fused to the fluorescent protein Tag-RFP-T (P23HhRhoRFP). In heterozygotes, outer segments formed, and wild-type...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.