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Article

Accumulation of rhodopsin in late endosomes triggers photoreceptor cell degeneration.

PLoS genetics - 1 Feb 2009

Chinchore Yashodhan, Mitra Amitavo, Dolph Patrick J

Abstract excerpt

Progressive retinal degeneration is the underlying feature of many human retinal dystrophies. Previous work using Drosophila as a model system and analysis of specific mutations in human rhodopsin have uncovered a connection between rhodopsin endocytosis and retinal degeneration. In these mutants, rhodopsin and its regulatory protein arrestin form stable complexes, and endocytosis of these complexes causes...

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Identifiers

PMID: 19214218
DOI: 10.1371/journal.pgen.1000377
PMCID: PMC2633617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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