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Article

P23H rhodopsin accumulation causes transient disruptions to synaptic protein levels in rod photoreceptors in a model of retinitis pigmentosa.

Disease models & mechanisms - 1 Jun 2025

Thompson Samantha L, Crowder Sophie M, Hekmatara Maryam, Sechrest Emily R, Deng Wen-Tao, Robichaux Michael A

Abstract excerpt

Rod photoreceptor neurons in the retina detect scotopic light through the visual pigment rhodopsin (Rho) in their outer segment (OS). Efficient Rho trafficking to the OS through the inner rod compartments is critical for long-term rod health. However, given the importance of protein trafficking to the OS, little is known about the trafficking of rod synaptic proteins. Furthermore, the subcellular impact of Rho...

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Identifiers

PMID: 40462724
DOI: 10.1242/dmm.052256
PMCID: PMC12233068

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