Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A new rhodopsin R135W mutation induces endoplasmic reticulum stress and apoptosis in retinal pigment epithelial cells.

Journal of cellular physiology - 1 Aug 2019

Yu Yixin, Xia Xiaobo, Li Haibo, Zhang Yangzhou, Zhou Xiaoyun, Jiang Haibo

Abstract excerpt

Rhodopsin mutations are associated with the autosomal-dominant form of retinitis pigmentosa (RP). Here we report simultaneous occurrence of RP associated with bilateral nanophthalmos and acute angle-closure glaucoma in patient with a new mutation in rhodopsin (R135W). ARPE-19 cells were transfected with myc-tagged wild-type (WT) and R135W rhodopsin constructs. The half-life of WT and R135W rhodopsin was analyzed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum Stress
Share to Glaucoma, Angle-Closure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microphthalmos

Share to Molecular Chaperones

Share to Retinal Pigment Epithelium

Share to Retinitis Pigmentosa

Share to Rhodopsin

Share to Unfolded Protein Response

Source

Open in PubMed Open full text

Identifiers

PMID: 30635925
DOI: 10.1002/jcp.28100
PMCID: PMC13483026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A new rhodopsin R135W mutation induces endoplasmic reticulum stress and apoptosis in retinal pigment epithelial cells.PMID 30635925Read ↗

Retinitis pigmentosa‑associated rhodopsin mutant T17M induces endoplasmic reticulum (ER) stress and sensitizes cells to ER stress-induced cell death.Semantic proximity Read ↗

The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy.Semantic proximity Read ↗

Subcellular localization of mutant P23H rhodopsin in an RFP fusion knock-in mouse model of retinitis pigmentosa.Semantic proximity Read ↗

Endoplasmic reticulum stress and rhodopsin accumulation in an organoid model of Retinitis Pigmentosa carrying a RHO pathogenic variantSemantic proximity Read ↗

Retinal Organoid Models Show Heterozygous Rhodopsin Mutation Favors Endoplasmic Reticulum Stress-Induced Apoptosis in Rods.Semantic proximity Read ↗

Subcellular localization of mutant P23H rhodopsin in an RFP fusion knockin mouse model of retinitis pigmentosaSemantic proximity Read ↗

Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa.Semantic proximity Read ↗

Mechanisms of Rhodopsin-Related Inherited Retinal Degeneration and Pharmacological Treatment StrategiesSemantic proximity Read ↗

The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa.Semantic proximity Read ↗

Rhodopsin-associated retinal dystrophy: Disease mechanisms and therapeutic strategiesSemantic proximity Read ↗

Endoplasmic reticulum stress in human photoreceptor diseases.Semantic proximity Read ↗

Targeting the Proteostasis Network in Rhodopsin Retinitis Pigmentosa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.