Article
The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration.
PLoS biology - 1 Apr 2014
Wang Shiuan, Tan Kai Li, Agosto Melina A, Xiong Bo, Yamamoto Shinya, Sandoval Hector, Jaiswal Manish, Bayat Vafa, Zhang Ke, Charng Wu-Lin, David Gabriela, Duraine Lita, Venkatachalam Kartik, Wensel Theodore G, Bellen Hugo J
Abstract excerpt
Rhodopsin mistrafficking can cause photoreceptor (PR) degeneration. Upon light exposure, activated rhodopsin 1 (Rh1) in Drosophila PRs is internalized via endocytosis and degraded in lysosomes. Whether internalized Rh1 can be recycled is unknown. Here, we show that the retromer complex is expressed in PRs where it is required for recycling endocytosed Rh1 upon light stimulation. In the absence of subunits of the...
Topics
- Animals
- Drosophila Proteins
- Drosophila melanogaster
- Endocytosis
- Light
- Lysosomes
- Mutation
- Photoreceptor Cells, Invertebrate
- Protein Transport
- Retinal Degeneration
- Rhodopsin
- Vesicular Transport Proteins