Network biology analysis of P23H rhodopsin interactome identifies protein and mRNA quality control mechanisms.

doi:10.1038/s41598-022-22316-8

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Network biology analysis of P23H rhodopsin interactome identifies protein and mRNA quality control mechanisms.

Scientific reports - 18 Oct 2022

Kim Kyle, Safarta Lance A, Chiang Wei-Chieh J, Coppinger Judith A, Lee Eun-Jin, Lin Jonathan H

Abstract excerpt

Rhodopsin is essential for phototransduction, and many rhodopsin mutations cause heritable retinal degenerations. The P23H rhodopsin variant generates a misfolded rhodopsin protein that photoreceptors quickly target for degradation by mechanisms that are incompletely understood. To gain insight into how P23H rhodopsin is removed from rods, we used mass spectrometry to identify protein interaction partners of P23H...

Topics

Mice
Animals
Rhodopsin
RNA, Messenger
Retinal Rod Photoreceptor Cells
Retinal Degeneration
Mutation
Quality Control
Ubiquitins
Biology
Disease Models, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 36258031
DOI: 10.1038/s41598-022-22316-8
PMCID: PMC9579138

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics