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Article

Inhibition of CaMKII does not attenuate cardiac hypertrophy in mice with dysfunctional ryanodine receptor.

PloS one - 1 Jan 2014

Chakraborty Asima, Pasek Daniel A, Huang Tai-Qin, Gomez Angela C, Yamaguchi Naohiro, Anderson Mark E, Meissner Gerhard

Abstract excerpt

In cardiac muscle, the release of calcium ions from the sarcoplasmic reticulum through ryanodine receptor ion channels (RyR2s) leads to muscle contraction. RyR2 is negatively regulated by calmodulin (CaM) and by phosphorylation of Ca2+/CaM-dependent protein kinase II (CaMKII). Substitution of three amino acid residues in the CaM binding domain of RyR2 (RyR2-W3587A/L3591D/F3603A, RyR2ADA) impairs inhibition of...

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Identifiers

PMID: 25093823
DOI: 10.1371/journal.pone.0104338
PMCID: PMC4122402

Genes

ADA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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