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Article

A Single Protein Kinase A or Calmodulin Kinase II Site Does Not Control the Cardiac Pacemaker Ca2+ Clock.

Circulation. Arrhythmia and electrophysiology - 1 Feb 2016

Wu Yuejin, Valdivia Héctor H, Wehrens Xander H T, Anderson Mark E

Abstract excerpt

BACKGROUND: Fight or flight heart rate (HR) increases depend on protein kinase A (PKA)- and calmodulin kinase II (CaMKII)-mediated enhancement of Ca(2+) uptake and release from sarcoplasmic reticulum (SR) in sinoatrial nodal cells (SANC). However, the impact of specific PKA and CaMKII phosphorylation sites on HR is unknown. METHODS AND RESULTS: We systematically evaluated validated PKA and CaMKII target sites on...

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Identifiers

PMID: 26857906
DOI: 10.1161/CIRCEP.115.003180
PMCID: PMC4755317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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