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Article

Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice.

American journal of physiology. Heart and circulatory physiology - 1 Oct 2009

Schaeffer Paul J, Desantiago Jaime, Yang John, Flagg Thomas P, Kovacs Attila, Weinheimer Carla J, Courtois Michael, Leone Teresa C, Nichols Colin G, Bers Donald M, Kelly Daniel P

Abstract excerpt

To define the necessity of calcineurin (Cn) signaling for cardiac maturation and function, the postnatal phenotype of mice with cardiac-specific targeted ablation of the Cn B1 regulatory subunit (Ppp3r1) gene (csCnb1(-/-) mice) was characterized. csCnb1(-/-) mice develop a lethal cardiomyopathy, characterized by impaired postnatal growth of the heart and combined systolic and diastolic relaxation abnormalities,...

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Source

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Identifiers

PMID: 19700627
DOI: 10.1152/ajpheart.00152.2009
PMCID: PMC2770758

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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