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Article

Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity.

American journal of physiology. Heart and circulatory physiology - 1 Mar 2004

Schultz Jo El J, Glascock Betty J, Witt Sandra A, Nieman Michelle L, Nattamai Kalpana J, Liu Lynne H, Lorenz John N, Shull Gary E, Kimball Thomas R, Periasamy Muthu

Abstract excerpt

We recently developed a mouse model with a single functional allele of Serca2 (Serca2+/-) that shows impaired cardiac contractility and relaxation without overt heart disease. The goal of this study was to test the hypothesis that chronic reduction in sarco(endo)plasmic reticulum Ca(2+)-ATPase (S...

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Source

Identifiers

PMID: 14630633
DOI: 10.1152/ajpheart.00720.2003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14630633-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity.PMID 14630633Read ↗

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Angiotensin II-mediated phenotypic cardiomyocyte remodeling leads to age-dependent cardiac dysfunction and failure.Semantic proximity Read ↗

Transgenic rat hearts overexpressing SERCA2a show improved contractility under baseline conditions and pressure overloadSemantic proximity Read ↗

Subclinical abnormalities in sarcoplasmic reticulum Ca(2+) release promote eccentric myocardial remodeling and pump failure death in response to pressure overload.Semantic proximity Read ↗

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Cardiac-specific overexpression of a high Ca2+ affinity mutant of SERCA2a attenuates in vivo pressure overload cardiac hypertrophy.Semantic proximity Read ↗

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