Article
Exercise training before cardiac-specific Serca2 disruption attenuates the decline in cardiac function in mice.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Dec 2010
Ericsson Madelene, Sjåland Cecilie, Andersson Kristin B, Sjaastad Ivar, Christensen Geir, Sejersted Ole M, Ellingsen Øyvind
Abstract excerpt
In the heart, function of the sarco(endo)plasmic Ca(2+)-ATPase (SERCA2) is closely linked to contractility, cardiac function, and aerobic fitness. SERCA2 function can be increased by high-intensity interval training, whereas reduced SERCA2 abundance is associated with impaired cardiac function. The working hypothesis was, therefore, that exercise training before cardiomyocyte-specific disruption of the Serca2...
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