Article
Role of cardiac ryanodine receptor calmodulin-binding domains in mediating the action of arrhythmogenic calmodulin N-domain mutation N54I.
The FEBS journal - 1 Jun 2020
Søndergaard Mads T, Liu Yingjie, Guo Wenting, Wei Jinhong, Wang Ruiwu, Brohus Malene, Overgaard Michael T, Chen S R Wayne
Abstract excerpt
The Ca2+ -sensing protein calmodulin (CaM) inhibits cardiac ryanodine receptor (RyR2)-mediated Ca2+ release. CaM mutations associated with arrhythmias and sudden cardiac death have been shown to diminish CaM-dependent inhibition of RyR2, but the underlying mechanisms are not well understood. Nearly all arrhythmogenic CaM mutations identified are located in the C-domain of CaM and exert marked effects on Ca2+...
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