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Article

Cardiac-specific overexpression of a high Ca2+ affinity mutant of SERCA2a attenuates in vivo pressure overload cardiac hypertrophy.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2003

Nakayama Hiroyuki, Otsu Kinya, Yamaguchi Osamu, Nishida Kazuhiko, Date Moto-o, Hongo Kenichi, Kusakari Yoichiro, Toyofuku Toshihiko, Hikoso Shungo, Kashiwase Kazunori, Takeda Toshihiro, Matsumura Yasushi, Kurihara Satoshi, Hori Masatsugu, Tada Michihiko

Abstract excerpt

In cardiomyocytes, calcium plays important roles as a signal in cardiac hypertrophy and contraction-relaxation cycling. Elevation of Ca2+ concentration in myoplasm is associated with the onset and progression of hypertrophy as well as the enhancement of contractility. The cardiac Ca2+ ATPase (SERCA2a) of the sarcoplasmic reticulum plays a dominant role in lowering cytoplasmic calcium levels during relaxation and...

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PMID: 12424227
DOI: 10.1096/fj.02-0474fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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