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Article

Effects of chronic stress on the onset and progression of Huntington's disease in transgenic mice.

Neurobiology of disease - 1 Nov 2014

Mo Christina, Renoir Thibault, Hannan Anthony J

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disease caused by a tandem repeat mutation encoding an expanded polyglutamine tract. Our previous work showed that memory deficits in HD transgenic mice could be accelerated by increased levels of stress hormone, while memory in WT mice remained unaffected. HD patients experience higher levels of stress compared to the general population and symptoms of HD also...

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Identifiers

PMID: 25088714
DOI: 10.1016/j.nbd.2014.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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