Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The absence of the aryl hydrocarbon receptor in the R6/1 transgenic mouse model of Huntington's disease improves the neurological phenotype.

Behavioural brain research - 25 Jun 2021

Angeles-López Quetzalli D, García-Lara Lucia, Aguirre-Pineda Nicolás, Castañeda-Arellano Rolando, Elizondo-Azuela Guillermo, Pérez-Severiano Francisca, Segovia José

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an abnormal CAG repeat expansion in the huntingtin gene coding for a protein with an elongated polyglutamine sequence. HD patients present choreiform movements, which are caused by the loss of neurons in the striatum and cerebral cortex. Previous reports indicate that the absence of the aryl hydrocarbon receptor (AhR) protects mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal
Share to Gliosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntingtin Protein

Share to Huntington Disease

Share to Mice, Knockout

Share to Mice, Transgenic

Share to Motor Activity

Share to Receptors, Aryl Hydrocarbon

Source

Identifiers

PMID: 33684424
DOI: 10.1016/j.bbr.2021.113230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The absence of the aryl hydrocarbon receptor in the R6/1 transgenic mouse model of Huntington's disease improves the neurological phenotype.PMID 33684424Read ↗

Molecular and behavioral analysis of the R6/1 Huntington's disease transgenic mouse.Semantic proximity Read ↗

Longitudinal analysis of the behavioural phenotype in R6/1 (C57BL/6J) Huntington's disease transgenic mice.Semantic proximity Read ↗

Progressive CAG expansion in the brain of a novel R6/1-89Q mouse model of Huntington's disease with delayed phenotypic onset.Semantic proximity Read ↗

Environmental enrichment slows disease progression in R6/2 Huntington's disease mice.Semantic proximity Read ↗

Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic miceSemantic proximity Read ↗

The R6 lines of transgenic mice: A model for screening new therapies for Huntington's diseaseSemantic proximity Read ↗

Sex-Dependent Changes in Social Behaviors in Motor Pre-Symptomatic R6/1 MiceSemantic proximity Read ↗

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.Semantic proximity Read ↗

A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington's disease.Semantic proximity Read ↗

Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease.Semantic proximity Read ↗

Responses to environmental enrichment differ with sex and genotype in a transgenic mouse model of Huntington's disease.Semantic proximity Read ↗

Antagonistic pleiotropy in mice carrying a CAG repeat expansion in the range causing Huntington’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.