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Article

Novel ethological endophenotypes in a transgenic mouse model of Huntington's disease.

Behavioural brain research - 1 Jan 2015

Mo Christina, Renoir Thibault, Hannan Anthony J

Abstract excerpt

Huntington's disease (HD) is an autosomal dominant, neurodegenerative disorder with a characteristic triad of cognitive, affective and motor symptoms. Transgenic HD mice show excellent construct and face validity for many of these symptoms, however the decline in some facets of every day activity in humans is difficult to model. One approach is the assessment of species-relevant behaviors. Here we described three...

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PMID: 24747660
DOI: 10.1016/j.bbr.2014.04.003

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