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Article

Responses to environmental enrichment differ with sex and genotype in a transgenic mouse model of Huntington's disease.

PloS one - 12 Feb 2010

Wood Nigel I, Carta Valentina, Milde Stefan, Skillings Elizabeth A, McAllister Catherine J, Ang Y L Mabel, Duguid Alasdair, Wijesuriya Nadeev, Afzal Samira Mohd, Fernandes Joe X, Leong T W, Morton A Jennifer, Morton Jennifer

Abstract excerpt

BACKGROUND: Environmental enrichment (EE) in laboratory animals improves neurological function and motor/cognitive performance, and is proposed as a strategy for treating neurodegenerative diseases. EE has been investigated in the R6/2 mouse model of Huntington's disease (HD), where increased social interaction, sensory stimulation, exploration, and physical activity improved survival. We have also shown...

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Identifiers

PMID: 20174443
DOI: 10.1371/journal.pone.0009077
PMCID: PMC2820540

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Source receipt: pubmed, retrieved 7 Sept 2026.

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