Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Responses to environmental enrichment differ with sex and genotype in a transgenic mouse model of Huntington's disease.

PloS one - 12 Feb 2010

Wood Nigel I, Carta Valentina, Milde Stefan, Skillings Elizabeth A, McAllister Catherine J, Ang Y L Mabel, Duguid Alasdair, Wijesuriya Nadeev, Afzal Samira Mohd, Fernandes Joe X, Leong T W, Morton A Jennifer, Morton Jennifer

Abstract excerpt

BACKGROUND: Environmental enrichment (EE) in laboratory animals improves neurological function and motor/cognitive performance, and is proposed as a strategy for treating neurodegenerative diseases. EE has been investigated in the R6/2 mouse model of Huntington's disease (HD), where increased soc...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Husbandry
Share to Circadian Rhythm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntington Disease

Share to Mice, Inbred CBA

Share to Motor Activity

Share to Rotarod Performance Test

Share to Swimming

Share to Trinucleotide Repeat Expansion

Source

Open in PubMed Open full text

Identifiers

PMID: 20174443
DOI: 10.1371/journal.pone.0009077
PMCID: PMC2820540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20174443-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Responses to environmental enrichment differ with sex and genotype in a transgenic mouse model of Huntington's disease.PMID 20174443Read ↗

Environmental enrichment slows disease progression in R6/2 Huntington's disease mice.Semantic proximity Read ↗

Beneficial effects of environmental enrichment and food entrainment in the R6/2 mouse model of Huntington's disease.Semantic proximity Read ↗

Environmental stimulation increases survival in mice transgenic for exon 1 of the Huntington's disease gene.Semantic proximity Read ↗

Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington's disease mice.Semantic proximity Read ↗

Detection of early behavioral markers of Huntington's disease in R6/2 mice employing an automated social home cage.Semantic proximity Read ↗

Novel ethological endophenotypes in a transgenic mouse model of Huntington's disease.Semantic proximity Read ↗

Sex-Dependent Changes in Social Behaviors in Motor Pre-Symptomatic R6/1 MiceSemantic proximity Read ↗

Nature, nurture and neurology: gene-environment interactions in neurodegenerative disease. FEBS Anniversary Prize Lecture delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw.Semantic proximity Read ↗

Sex‐specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosisSemantic proximity Read ↗

Effects of chronic stress on the onset and progression of Huntington's disease in transgenic mice.Semantic proximity Read ↗

Environmental Enrichment Prevents Transcriptional Disturbances Induced by Alpha-Synuclein OverexpressionSemantic proximity Read ↗

Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.