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Article

ALS-Plus syndrome: non-pyramidal features in a large ALS cohort.

Journal of the neurological sciences - 15 Oct 2014

McCluskey Leo, Vandriel Shannon, Elman Lauren, Van Deerlin Vivianna M, Powers John, Boller Ashley, Wood Elisabeth McCarty, Woo John, McMillan Corey T, Rascovsky Katya, Grossman Murray

Abstract excerpt

OBJECTIVE: Autopsy studies show widespread pathology in amyotrophic lateral sclerosis (ALS), but clinical surveys of multisystem disease in ALS are rare. We investigated ALS-Plus syndrome, an understudied group of patients with clinical features extending beyond pyramidal and neuromuscular systems with or without cognitive/behavioral deficits. METHODS: In a large, consecutively-ascertained cohort of 550 patients...

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Source

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Identifiers

PMID: 25086858
DOI: 10.1016/j.jns.2014.07.022
PMCID: PMC4177937

Genes

SOD1
TARDBP
VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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