Article
ALS phenotype is influenced by age, sex, and genetics: A population-based study.
Neurology - 25 Feb 2020
Chiò Adriano, Moglia Cristina, Canosa Antonio, Manera Umberto, D'Ovidio Fabrizio, Vasta Rosario, Grassano Maurizio, Brunetti Maura, Barberis Marco, Corrado Lucia, D'Alfonso Sandra, Iazzolino Barbara, Peotta Laura, Sarnelli Maria Francesca, Solara Valentina, Zucchetti Jean Pierre, De Marchi Fabiola, Mazzini Letizia, Mora Gabriele, Calvo Andrea
Abstract excerpt
OBJECTIVE: To assess the determinants of amyotrophic lateral sclerosis (ALS) phenotypes in a population-based cohort. METHODS: The study population included 2,839 patients with ALS diagnosed in Piemonte, Italy (1995-2015). Patients were classified according to motor (classic, bulbar, flail arm, flail leg, predominantly upper motor neuron [PUMN], respiratory) and cognitive phenotypes (normal, ALS with cognitive...
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