The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology.

doi:10.1038/s41582-024-00961-z

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Article

The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology.

Nature reviews. Neurology - 1 Jun 2024

Benatar Michael, Wuu Joanne, Huey Edward D, McMillan Corey T, Petersen Ronald C, Postuma Ronald, McHutchison Caroline, Dratch Laynie, Arias Jalayne J, Crawley Anita, Houlden Henry, McDermott Michael P, Cai Xueya, Thakur Neil, Boxer Adam, Rosen Howard, Boeve Bradley F, Dacks Penny, Cosentino Stephanie, Abrahams Sharon, Shneider Neil, Lingor Paul, Shefner Jeremy, Andersen Peter M, Al-Chalabi Ammar, Turner Martin R

Abstract excerpt

Increasing appreciation of the phenotypic and biological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, alongside evolving biomarker evidence for a pre-symptomatic stage of disease and observations that this stage of disease might not always be clinically silent, is challenging traditional views of these disorders. These advances have highlighted the need to adapt ingrained...

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PMID: 38769202
DOI: 10.1038/s41582-024-00961-z
PMCID: PMC11216694

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