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Article

Extra-motor abnormalities in amyotrophic lateral sclerosis: another layer of heterogeneity.

Expert review of neurotherapeutics - 1 Jun 2017

McCombe P A, Wray N R, Henderson R D

Abstract excerpt

INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease defined by the presence of muscle weakness. The motor features of disease are heterogeneous in site of onset and progression. There are also extra-motor features in some patients. The genetic basis for extra-motor features is uncertain. The heterogeneity of ALS is an issue for clinical trials. Areas covered: This paper reviews the...

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Identifiers

PMID: 27983884
DOI: 10.1080/14737175.2017.1273772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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