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Article

Cognitive and Behavioural Profile of SOD1-ALS Across the ALS-FTD Spectrum: A Systematic Review.

International journal of molecular sciences - 7 Sept 2026

Ginanni Francesco, Nicoletti Francesco, Meoni Caterina, Becattini Lucrezia, Mancuso Michelangelo, Carlesi Cecilia, Bianchi Francesca

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is increasingly recognized as a multisystem disorder. However, SOD1-associated ALS has traditionally been regarded as an exclusively motor phenotype. This systematic review challenges that paradigm by characterizing the cognitive and behavioural profiles of SOD1 mutation-related ALS. Following PRISMA guidelines, a systematic PubMed search identified 17 eligible studies. Across...

Read the complete abstract on PubMed

Topics

Humans
Amyotrophic Lateral Sclerosis
Superoxide Dismutase-1
Frontotemporal Dementia
Cognition
Mutation

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Source

Open in PubMed Open full text

Identifiers

PMID: 42737854
DOI: 10.3390/ijms27177958
PMCID: PMC13565861

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Sept 2026.

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