Article
ALS motor phenotypes: a revised 'OPM' classification.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Aug 2026
Meyer Thomas, Ticozzi Nicola, Weber Markus, Ravits John, Lingor Paul, Kuźma-Kozakiewicz Magdalena, Boentert Matthias, Grehl Torsten, Corcia Philippe, Povedano Panadés Mónica, Maier André, Ingre Caroline, Cetin Hakan, Weydt Patrick, Lunetta Christian, van den Berg Leonard, Ludolph Albert C, Brenner David, Turner Martin R, Genge Angela
Abstract excerpt
BACKGROUND: Defining motor phenotypes in amyotrophic lateral sclerosis (ALS) is important for individualized care and optimal therapeutic trial design. The "ALS-OPM" classification is based on the onset region (O), the propagation of motor symptoms (P), and the degree of clinical upper (UMN) and/or lower (LMN) motor neuron dysfunction (M). METHODS: An international ALS expert focus group was held in September...
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