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Motor neuron disease-frontotemporal dementia: a clinical continuum.

Expert review of neurotherapeutics - 1 May 2015

Devenney Emma, Vucic Steve, Hodges John R, Kiernan Matthew C

Abstract excerpt

Overlap between motor neuron disease (MND) and frontotemporal dementia (FTD) occurs at clinical, genetic and pathological levels, and has been recently strengthened through the discovery of the C9orf72 genetic expansion. MND is now considered to be a multisystem disorder in which cognitive involvement may be present and, in some cases, may evolve to frank FTD. Identifying cognitive features in MND can be...

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C9orf72 Protein
Cognition
Frontotemporal Dementia
Motor Neuron Disease
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25865485
DOI: 10.1586/14737175.2015.1034108

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