Back to search

Article

Amyotrophic Lateral Sclerosis: Advances in Diagnosis, Pathophysiology, and Emerging Therapeutic Strategies

2025-08-05

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease, characterized by progressive degeneration of upper and lower motor neurons. Clinically heterogeneous, ALS presents with varying patterns of muscle weakness, spasticity, and atrophy, ultimately impairing mobility, communication, swallowing, and respiration. The pathogenesis of ALS involves a complex interplay of genetic and environ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3ceca239-7872-5ea5-96c9-c53fecda841f
DOI
10.20944/preprints202508.0269.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Amyotrophic Lateral Sclerosis: Advances in Diagnosis, Pathophysiology, and Emerging Therapeutic StrategiesDOI 10.20944/preprints202508.0269.v1
Evaluation and management of amyotrophic lateral sclerosis.Semantic proximity
Amyotrophic Lateral Sclerosis and Other Motor Neuron DiseasesSemantic proximity
Genetic architecture of amyotrophic lateral sclerosis: a comprehensive review.Semantic proximity
Amyotrophic lateral sclerosis.Semantic proximity
New ALS-Related Genes Expand the Spectrum Paradigm of Amyotrophic Lateral Sclerosis.Semantic proximity
Amyotrophic lateral sclerosis.Semantic proximity
Advances and challenges in understanding the multifaceted pathogenesis of amyotrophic lateral sclerosis.Semantic proximity
Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS).Semantic proximity
ALS motor phenotypes: a revised 'OPM' classification.Semantic proximity
Amyotrophic lateral sclerosis. Insights from genetics.Semantic proximity
Amyotrophic Lateral Sclerosis (ALS): An Overview of Genetic and Metabolic Signaling Mechanisms.Semantic proximity
Amyotrophic lateral sclerosis: recent advances in understanding disease mechanisms.Semantic proximity
Select a neighboring publication to make it the new centre.