Article
The yeast prefoldin-like URI-orthologue Bud27 associates with the RSC nucleosome remodeler and modulates transcription.
Nucleic acids research - 1 Sept 2014
Mirón-García María Carmen, Garrido-Godino Ana Isabel, Martínez-Fernández Verónica, Fernández-Pevida Antonio, Cuevas-Bermúdez Abel, Martín-Expósito Manuel, Chávez Sebastián, de la Cruz Jesús, Navarro Francisco
Abstract excerpt
Bud27, the yeast orthologue of human URI/RMP, is a member of the prefoldin-like family of ATP-independent molecular chaperones. It has recently been shown to mediate the assembly of the three RNA polymerases in an Rpb5-dependent manner. In this work, we present evidence of Bud27 modulating RNA pol II transcription elongation. We show that Bud27 associates with RNA pol II phosphorylated forms (CTD-Ser5P and...
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