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Abundance of the RSC nucleosome-remodeling complex is important for the cells to tolerate DNA damage in Saccharomyces cerevisiae.

FEBS letters - 6 Nov 2002

Koyama Hirofumi, Itoh Masayuki, Miyahara Kohji, Tsuchiya Eiko

Abstract excerpt

The essential Nps1p/Sth1p is a catalytic subunit of the nucleosome-remodeling complex, RSC, of Saccharomyces cerevisiae that can alter nucleosome structure by using the energy of ATP hydrolysis. Besides the ATPase domain, Nps1p harbors the bromodomain, of which the function(s) have not yet been defined. We have isolated a temperature-sensitive mutant allele of NPS1, nps1-13, which has amino acid substitutions...

Topics

Cell Cycle Proteins
Conserved Sequence
DNA Damage
DNA, Fungal
Fungal Proteins
Macromolecular Substances
Mutation
Nuclear Proteins
Nucleosomes
Phenotype
Protein Structure, Tertiary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Subunits

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Temperature

Source

Identifiers

PMID: 12417315
DOI: 10.1016/s0014-5793(02)03504-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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