Article
The RSC chromatin remodeling complex bears an essential fungal-specific protein module with broad functional roles.
Genetics - 1 Feb 2006
Wilson Boris, Erdjument-Bromage Hediye, Tempst Paul, Cairns Bradley R
Abstract excerpt
RSC is an essential and abundant ATP-dependent chromatin remodeling complex from Saccharomyces cerevisiae. Here we show that the RSC components Rsc7/Npl6 and Rsc14/Ldb7 interact physically and/or functionally with Rsc3, Rsc30, and Htl1 to form a module important for a broad range of RSC functions. A strain lacking Rsc7 fails to properly assemble RSC, which confers sensitivity to temperature and to agents that...
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