Article
RSC Nucleosome-remodeling complex plays prominent roles in transcriptional regulation throughout budding yeast gametogenesis.
Bioscience, biotechnology, and biochemistry - 1 Apr 2004
Koyama Hirofumi, Nagao Taka-aki, Inai Tomomi, Miyahara Kohji, Hayasida Yasufumi, Shirahige Katsuhiko, Tsuchiya Eiko
Abstract excerpt
RSC is a nucleosome-remodeling complex of Saccharomyces cerevisiae essential for growth that can alter histone-DNA interaction by using the energy of ATP hydrolysis. Nps1p/Sth1p is an ATPase subunit of RSC. A mutation in the conserved ATPase domain of Nps1p causes a sporulation defect with decreased expression of early meiotic genes, especially IME2. This defect is partially suppressed by the overexpression of...
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