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Article

Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host

21 Sept 2006

Abstract excerpt

Protein aggregation is an established pathogenic mechanism in Alzheimer's disease, but little is known about the initiation of this process in vivo. Intracerebral injection of dilute, amyloid-beta (Abeta)-containing brain extracts from humans with Alzheimer's disease or beta-amyloid precursor protein (APP) transgenic mice induced cerebral beta-amyloidosis and associated pathology in APP transgenic mice in a time-...

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PMID: 16990547
DOI: 10.1126/science.1131864

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