Article

P2X2 receptor subunit interfaces are missense variant hotspots where mutations tend to increase apparent ATP affinity

2021-03-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Purpose</h4> P2X receptors (P2XRs) are trimeric ligand-gated ion channels (LGICs) that open a cation-selective pore in response to ATP binding to their large extracellular domain (ECD). The seven known P2XR subtypes can assemble as homo- or heterotrimeric complexes and contribute to numerous physiological functions, including nociception, inflammation and hearing. The overall...

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Literature Corpus work: 9e5dfdd4-9bc9-524c-818a-49fefb045ff9
DOI: 10.1101/2021.03.26.436616

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