Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and functional analysis of Mre11-3.

Nucleic acids research - 1 Jan 2004

Arthur L Matthew, Gustausson Karin, Hopfner Karl-Peter, Carson Christian T, Stracker Travis H, Karcher Annette, Felton Diana, Weitzman Matthew D, Tainer John, Carney James P

Abstract excerpt

The Mre11, Rad50 and Nbs1 proteins make up the conserved multi-functional Mre11 (MRN) complex involved in multiple, critical DNA metabolic processes including double-strand break repair and telomere maintenance. The Mre11 protein is a nuclease with broad substrate recognition, but MRN-dependent processes requiring the nuclease activity are not clearly defined. Here, we report the functional and structural...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Models, Molecular
Share to MRE11 Homologue Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Nuclear Proteins

Share to Acid Anhydride Hydrolases

Share to Cell Cycle Proteins

Share to DNA-Binding Proteins

Share to DNA Repair Enzymes

Share to Exonucleases

Source

Open in PubMed Open full text

Identifiers

PMID: 15047855
DOI: 10.1093/nar/gkh343
PMCID: PMC390353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and functional analysis of Mre11-3.PMID 15047855Read ↗

Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.Semantic proximity Read ↗

Mutation of Conserved Mre11 Residues Alter Protein Dynamics to Separate Nuclease Functions.Semantic proximity Read ↗

Biochemical and structural characterization of analogs of MRE11 breast cancer-associated mutant F237C.Semantic proximity Read ↗

A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex.Semantic proximity Read ↗

Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.Semantic proximity Read ↗

Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity.Semantic proximity Read ↗

Mre11 assembles linear DNA fragments into DNA damage signaling complexes.Semantic proximity Read ↗

Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.Semantic proximity Read ↗

A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Complex Functions in Yeast and HumansSemantic proximity Read ↗

Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairSemantic proximity Read ↗

Formation of the yeast Mre11-Rad50-Xrs2 complex is correlated with DNA repair and telomere maintenance.Semantic proximity Read ↗

MRE11 as a molecular signature and therapeutic target for cancer treatment with radiotherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.