Article

Mre11-Rad50 oligomerization promotes DNA double-strand break repair

2021-08-27

Abstract excerpt

<title>Abstract</title> <p>The conserved Mre11-Rad50 (MR) complex is crucial for the detection, signaling, end tethering and processing of DNA double-strand breaks (DSBs). While it was known for decades that MR foci formation at DSBs accompanies repair, the underlying molecular assembly mechanisms and functional implications remained unclear. Combining pathway reconstitution in electron microscopy, biochemical as...

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Literature Corpus work: 3c80dc1e-2f51-5d1d-87f0-b47c8ca97bcc
DOI: 10.21203/rs.3.rs-811984/v1

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