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Article

Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity.

Genetics - 1 Dec 2005

Krogh Berit O, Llorente Bertrand, Lam Alicia, Symington Lorraine S

Abstract excerpt

The Mre11-Rad50-Xrs2 complex is involved in DNA double-strand break repair, telomere maintenance, and the intra-S phase checkpoint. The Mre11 subunit has nuclease activity in vitro, but the role of the nuclease in DNA repair and telomere maintenance remains controversial. We generated six mre11 alleles with substitutions of conserved residues within the Mre11-phosphoesterase motifs and compared the phenotypes...

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Identifiers

PMID: 16143598
DOI: 10.1534/genetics.105.049478
PMCID: PMC1456084

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