Article
Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination.
The EMBO journal - 2 Nov 1998
Furuse M, Nagase Y, Tsubouchi H, Murakami-Murofushi K, Shibata T, Ohta K
Abstract excerpt
UNLABELLED: In Saccharomyces cerevisiae, Mre11 protein is involved in both double-strand DNA break (DSB) repair and meiotic DSB formation. Here, we report the correlation of nuclease and DNA-binding activities of Mre11 with its functions in DNA repair and meiotic DSB formation. Purified Mre11 bou...
Topics
- Bacteriophage M13
- Chromatin
- DNA Repair
- DNA, Circular
- DNA, Single-Stranded
- DNA-Binding Proteins
- Deoxyribonucleases
- Endodeoxyribonucleases
- Exodeoxyribonucleases
- Fungal Proteins
- Meiosis
- Methyl Methanesulfonate
- Mitosis
- Mutation
- Phenotype
- Protein Conformation
- Recombination, Genetic
- Saccharomyces cerevisiae