Sequence of gating charge movement and pore gating in HERG activation and deactivation pathways.

Abstract excerpt

KV11.1 voltage-gated K(+) channels are noted for unusually slow activation, fast inactivation, and slow deactivation kinetics, which tune channel activity to provide vital repolarizing current during later stages of the cardiac action potential. The bulk of charge movement in human ether-a-go-go-related gene (hERG) is slow, as is return of charge upon repolarization, suggesting that the rates of hERG channel...

Topics

• Animals
• ERG1 Potassium Channel
• Ether-A-Go-Go Potassium Channels
• Humans
• Ion Channel Gating
• Kinetics
• Membrane Potentials
• Mutation
• Oocytes
• Patch-Clamp Techniques
• Xenopus