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Article

Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channels.

The Journal of biological chemistry - 22 Aug 2014

Thomson Steven J, Hansen Angela, Sanguinetti Michael C

Abstract excerpt

During the repolarization phase of a cardiac action potential, hERG1 K(+) channels rapidly recover from an inactivated state then slowly deactivate to a closed state. The resulting resurgence of outward current terminates the plateau phase and is thus a key regulator of action potential duration of cardiomyocytes. The intracellular N-terminal domain of the hERG1 subunit is required for slow deactivation of the...

Topics

Animals
Ether-A-Go-Go Potassium Channels
Gene Silencing
Humans
Kinetics
Mutation
Xenopus laevis

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 25008322
DOI: 10.1074/jbc.M114.582437
PMCID: PMC4156076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channels.PMID 25008322Read ↗

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