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Article

hERG potassium channel gating is mediated by N- and C-terminal region interactions.

The Journal of general physiology - 1 Mar 2011

Gustina Ahleah S, Trudeau Matthew C

Abstract excerpt

Human ether-á-go-go-related gene (hERG) potassium channels have voltage-dependent closing (deactivation) kinetics that are unusually slow. A Per-Arnt-Sim (PAS) domain in the cytoplasmic N-terminal region of hERG regulates slow deactivation by making a direct interaction with another part of the hERG channel. The mechanism for slow deactivation is unclear, however, because the other regions of the channel that...

Topics

Animals
Binding Sites
ERG1 Potassium Channel
Ether-A-Go-Go Potassium Channels
Humans
Ion Channel Gating
Kinetics
Membrane Potentials
Mutation
Nucleotides, Cyclic
Potassium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Interaction Domains and Motifs

Protein Interaction Mapping

Protein Structure, Tertiary

Recombinant Fusion Proteins

Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 21357734
DOI: 10.1085/jgp.201010582
PMCID: PMC3047612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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hERG potassium channel gating is mediated by N- and C-terminal region interactions.PMID 21357734Read ↗

An intracellular hydrophobic nexus is critical for slow deactivation in hERG channelsSemantic proximity Read ↗

Role of intracellular domains in the function of the herg potassium channel.Semantic proximity Read ↗

Two mutations at different positions in the CNBH domain of the hERG channel accelerate deactivation and impair the interaction with the EAG domain.Semantic proximity Read ↗

Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels.Semantic proximity Read ↗

A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels.Semantic proximity Read ↗

Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channels.Semantic proximity Read ↗

Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels.Semantic proximity Read ↗

Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channels.Semantic proximity Read ↗

Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation.Semantic proximity Read ↗

Interactions between the N-terminal tail and the gating machinery of hERG K⁺ channels both in closed and open/inactive states.Semantic proximity Read ↗

Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel.Semantic proximity Read ↗

Sequence of gating charge movement and pore gating in HERG activation and deactivation pathways.Semantic proximity Read ↗

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