Article
Threonine-290 regulates nuclear translocation of the human pregnane X receptor through its phosphorylation/dephosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1.
Drug metabolism and disposition: the biological fate of chemicals - 1 Oct 2014
Sugatani Junko, Hattori Yoshiki, Noguchi Yuji, Yamaguchi Masahiko, Yamazaki Yasuhiro, Ikari Akira
Abstract excerpt
The human pregnane X receptor (hPXR) is recognized as a xenobiotic-sensing nuclear receptor that transcriptionally regulates the gene expression of drug-metabolizing enzymes and transporters. Our study elucidates the mechanism by which the localization of hPXR is regulated through threonine-290. A phosphomimetic mutation at threonine-290 (T290D) retained hPXR in the cytoplasm of HepG2, HuH6, and SW480 cells in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.